- Essential fatty acids Linus Pauling Institute
- Siguel E, 1998, Diagnosing Essential Fatty Acid Deficiency Circulation
- Morley JE, Essential fatty acid deficiency Merck Manual, Professional Version
Fatty Acids
What are fatty acids?
Naturally occurring fatty acids usually contain 2-28 carbon atoms, each with one or two hydrogen atoms attached, a methyl group (CH3) on one end and a carboxylic group (COOH) on the other one.
Fatty acids belong to fats, which belong to lipids.
In foods, fatty acids usually appear in combination with glycerol as triglycerides and only in small amounts as free fatty acids, which are not bound to other molecules.
Chart 1. A List of Fatty Acids in the Human Diet |
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SHORT-Chain FA (SCFA) |
MEDIUM-Chain FA (MCFA) |
LONG-Chain FA (LCFA) |
VERY LONG Chain FA (VLCFA) |
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SATURATED FA |
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MONO-UNSATURATED FA | ||||
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POLY-UNSATURATED FA | ||||
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TRANS FA |
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Chart 1 legend: FA = fatty acid; Cn is the number of C atoms; The number after the colon means the number of the double bonds (saturated fatty acids have zero); the number after “n” tells at which C atom the first double bond appears.
Essential Fatty Acids
Essential fatty acids are necessary for the human life and health, but they cannot be produced in the human body, so you need to obtain them from food. There are two essential fatty acids [1]:
All other fatty acids can be produced in your body, so you do not need to get them from foods.
Essential Fatty Acid Deficiency
Essential fatty acid (EFA) deficiency is rare; it most commonly occurs in infants fed with diets low in EFA [3].
The main causes of essential fatty acid deficiency are [1,2]:
- Feeding infants with skim milk formula
- Chronic fat malabsorption in cystic fibrosis
- Severe malnutrition
- Low-fat diet (<5% energy from fats)
Symptoms of essential fatty acid deficiency include dry scaly rash, soft nails, slow wound healing, increased susceptibility for infections, short-term memory loss, difficulty concentrating, fainting, decreased visual acuity, sexual dysfunction and impaired growth in children [1,2].
Diagnosis of essential fatty acid deficiency can be made by finding increased eicosatrienoic acid : arachidonic acid ratio (>0.2) in the blood [1].
Treatment of essential fatty acids deficiency may include consuming walnut oil, which is high in both linoleic acid (LA) and alpha-linolenic acid (ALA) [2] or a combination of sunflower or corn oil (high in linoleic acid) and oily fish or fish oil supplements, which are high in eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA) (which are produced from ALA in the body and are responsible for the main effects of ALA).
Lipids
- FATTY ACIDS
- Saturated
- Monounsaturated
- Polyunsaturated
- Short-chain fatty acids (SCFAs)
- Medium-chain fatty acids (MCFAs)
- Long-chain fatty acids (LCFAs)
- Very long-chain fatty acids (VLCFAs)
- Monoglycerides
- Diglycerides
- Triglycerides
- Fructose
- Galactose
- Glucose
- Isomaltose
- Isomaltulose
- Lactose
- Maltose
- Mannose
- Sucrose
- Tagatose
- Trehalose
- Trehalulose
- Xylose
- Erythritol
- Glycerol
- Hydrogenated starch hydrolysates (HSH)
- Inositol
- Isomalt
- Lactitol
- Maltitol
- Mannitol
- Sorbitol
- Xylitol
- Fructo-oligosaccharides (FOS)
- Galacto-oligosaccharides (GOS)
- Human milk oligosaccharides (HMO)
- Isomalto-oligosaccharides (IMO)
- Maltotriose
- Mannan oligosaccharides (MOS)
- Raffinose, stachyose, verbascose
- SOLUBLE FIBER:
- Acacia (arabic) gum
- Agar-agar
- Algin-alginate
- Arabynoxylan
- Beta-glucan
- Beta mannan
- Carageenan gum
- Carob or locust bean gum
- Fenugreek gum
- Galactomannans
- Gellan gum
- Glucomannan or konjac gum
- Guar gum
- Hemicellulose
- Inulin
- Karaya gum
- Pectin
- Polydextrose
- Psyllium husk mucilage
- Resistant starches
- Tara gum
- Tragacanth gum
- Xanthan gum
- INSOLUBLE FIBER:
- Cellulose
- Chitin and chitosan
- Vitamin A - Retinol and retinal
- Vitamin B1 - Thiamine
- Vitamin B2 - Riboflavin
- Vitamin B3 - Niacin
- Vitamin B5 - Pantothenic acid
- Vitamin B6 - Pyridoxine
- Vitamin B7 - Biotin
- Vitamin B9 - Folic acid
- Vitamin B12 - Cobalamin
- Choline
- Vitamin C - Ascorbic acid
- Vitamin D - Ergocalciferol and cholecalciferol
- Vitamin E - Tocopherol
- Vitamin K - Phylloquinone
- Curcumin
- FLAVONOIDS:
- Anthocyanidins
- Flavanols: Proanthocyanidins
- Flavanones: Hesperidin
- Flavonols: Quercetin
- Flavones: Diosmin, Luteolin
- Isoflavones: daidzein, genistein
- Caffeic acid
- Chlorogenic acid
- Lignans
- Resveratrol
- Tannins
- Tannic acid
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